Osteoarthritis

Authors: Klinck MP, Frank D, Guillot M, Troncy E.
Journal: Can Vet J

Veterinarians contacted to identify cats diagnosed with osteoarthritis (OA) provided information on signalment, method of diagnosis, treatment and concurrent disease. Owners of 50 cats were interviewed to collect information on specific OA signs observed in the home, relating to mobility, self-maintenance, social and exploratory behavior, and activity and habits at diagnosis and after treatment. Mean age at diagnosis was 12 y; concurrent diseases were common (44%).

Authors: Christopher SA, Beetem J, Cook JL.
Journal: Vet Surg

329-34OBJECTIVE: To evaluate long-term (>1 year) outcomes with respect to function and complications in dogs undergoing TightRope (TR), tibial plateau leveling osteotomy (TPLO), or tibial tuberosity advancement (TTA) for treatment of cranial cruciate liga

Authors: Sullivan MO, Gordon-Evans WJ, Knap KE, Evans RB.
Journal: Vet Surg

OBJECTIVES:
To evaluate the efficacy of pulsed signal therapy (PST) in reducing pain and increasing function in dogs with osteoarthritis (OA) using a randomized, blinded, controlled clinical trial.
STUDY DESIGN:
Randomized, controlled, blinded clinical trial.
ANIMALS:
Adult dogs (n = 60) with moderate-to-severe clinical signs of OA.
METHODS:

Authors: Dingemanse WB, Van Bree HJ, Duchateau L, Gielen IM.
Journal: Vet Surg

OBJECTIVE:
To evaluate clinical and subchondral bone lesion differences between medial (MTRT-OC) and lateral trochlear ridge tarsocruralosteochondrosis (LTRT-OC).
STUDY DESIGN:
Retrospective case series.
ANIMALS:
Dogs (n = 66) with MTRT-OC or LTRT-OC.
METHODS:

Authors: Safra N, Johnson EG, Lit L, Foreman O, Wolf ZT, Aguilar M, Karmi N, Finno CJ, Bannasch DL.
Journal: JAVMA

Objective-To evaluate clinical manifestations, response to treatment, and outcome for Weimaraners with hypertrophic osteodystrophy (HOD). Design-Retrospective case series. Animals-53 dogs. Procedures-Medical records were reviewed for signalment, vaccination history, clinical signs, laboratory test results, response to treatment, and relapses. Radiographs were reviewed. Results-Clinical signs included pyrexia, lethargy, and ostealgia; signs involving the gastrointestinal, ocular, or cutaneous systems were detected. Of the 53 dogs, 28 (52.8%) had HOD-affected littermates.

Authors: Deluke AM, Allen DA, Wilson ER, Lineberger JA, Lehenbauer TW, Fabiani M, Poteet BA.
Journal: Can Vet J

Radiographic osteoarthritis scores were determined in 60 dogs up to 3 years following tibial plateau leveling osteotomy. Radiographs taken immediately following surgery and at long-term follow-up 1 to 3 years later were evaluated by 2 certified radiologists using a modified 32-point osteoarthritis scale. Changes in osteoarthritis scores were evaluated by paired t-tests and regression analysis. Sub-groups of dogs were formed to evaluate if osteoarthritis scores changed differently for follow-up periods of < 24 months compared with those > 24 months.

Authors: Ondreka N, Amort KH, Stock KF, Tellhelm B, Klumpp SW, Kramer M, Schmidt MJ.
Journal: Vet J

The aim of this study was to identify skeletal variations in the lumbosacral junction (LSJ) of the German shepherd dog (GSD) compared with other large breeds. The radiographic traits of the LSJ were investigated in a group of 733 GSDs and a control group of 334 dogs of other breeds that were matched in terms of size. Nine morphological and 17 morphometric traits were recorded and analysed. Furthermore, the possibility of a genetic basis for these radiographic features was evaluated by calculation of genetic variance components.

Authors: Ellenberger S, Snyder C.
Journal: JAAHA

A 3 mo old female Airedale terrier presented with decreased range of motion of the temporomandibular joint (TMJ), which was first recognized at weaning. Computed tomography (CT) revealed abnormal, bilateral ossification of the soft tissues extending from the region of the tympanic bullae to the medial aspect of the angular process of each mandible. Those ossified structures most closely approximated the location of the lateral pterygoid muscles. The ossified structures were present at presentation and initially manifested as complete ossification on the right side.

Authors: Zhang N, Dietrich MA, Lopez MJ.
Journal: Vet Surg

OBJECTIVE:
To identify the optimum intra-articular multipotent stromal cell (MSC) tissue source in the canine stifle.
STUDY DESIGN:
Experimental.
SAMPLE POPULATION:
Infrapatellar adipose tissue, synovium lining the joint capsule, and synovium surrounding the cranial cruciate ligament (CrCL) from normal stifles of 6 dogs.
METHODS:

Authors: Garner BC, Kuroki K, Stoker AM, Cook CR, Cook JL.
Journal: AJVR

Objective-To identify proteins with differential expression between healthy dogs and dogs with stifle joint osteoarthritis secondary to cranial cruciate ligament (CCL) disease. Sample-Serum and synovial fluid samples obtained from dogs with stifle joint osteoarthritis before (n = 10) and after (8) surgery and control dogs without osteoarthritis (9) and archived synovial membrane and articular cartilage samples obtained from dogs with stifle joint osteoarthritis (5) and dogs without arthritis (5).