Low back pain (LBP) is a leading cause of global disability. Multiple anatomical, cellular and molecular factors implicated in LBP, including degeneration of lumbar intervertebral discs (IVDs). We previously described a mouse model that displays behavioral symptoms of chronic LBP.
Long-term histological analysis of innervation & macrophage infiltration in a mouse model of intervertebral disc injury‐induced low back pain
Introduction of Disc Material into the Vertebral Canal by Fenestration of Thoracolumbar Discs Following Decompressive Surgery
OBJECTIVE: Intervertebral disc extrusion is a common disease affecting chondrodystrophic dogs. It has been reported that fenestration of thoracolumbar intervertebral discs reduces recurrence of disc extrusion and is associated with a low complication rate.
Neurologic and magnetic resonance imaging features of German Shepherd Dogs with cervical spondylomyelopathy: 10 cases (2006-2018)
OBJECTIVE: To describe the neurologic signs and MRI findings for German Shepherd Dogs (GSDs) with cervical spondylomyelopathy (CSM).
ANIMALS: 10 GSDs with confirmed CSM.
Accuracy of placement of pedicle screws in the thoracolumbar spine of dogs with spinal deformities with three‐dimensionally printed patient‐specific drill guides
OBJECTIVE: To determine the accuracy of pedicle screw placement in the thoracic spine of dogs with spinal deformities with three-dimensionally (3D) printed patient-specific drill guides.
OBJECTIVE: To determine a flexed position for radiographic diagnosis of atlantoaxial instability (AAI) and to identify radiographic measurement cutoffs to differentiate affected dogs from neurologically healthy toy breeds.
STUDY DESIGN: Retrospective case series and prospective case controls.
OBJECTIVE: To report the long-term outcome of nine dogs treated for caudal cervical spondylomyelopathy (CCSM) with surgical spinal fusion.
STUDY DESIGN: Short case series.
ANIMALS: Nine large-breed dogs.
Decompressive surgery for treatment of a dorsal compressive atlantoaxial band causing nonambulatory tetraparesis in three toy-breed dogs
CASE DESCRIPTION: 3 toy-breed dogs (a 5-year-old Pomeranian, a 12-year-old Pomeranian, and a 13-year-old Yorkshire Terrier) were evaluated because of a sudden onset of nonambulatory tetraparesis.
OBJECTIVE: To report the successful treatment of intervertebral disc protrusion with minimally invasive microsurgery in a large breed dog.
STUDY DESIGN: Retrospective case report.
BACKGROUND: In human medicine, fractures of the second cervical vertebra have been studied elaborately and categorized in detail. This is not the case in veterinary medicine where clinical decisions are often based on old studies focusing on the cervical spine in general.
Evaluation of intervertebral disc regeneration with injection of mesenchymal stem cells encapsulated in PEGDA-microcryogel delivery system using quantitative T2 mapping: a study in canines
Intervertebral disc degeneration (IDD), the primary cause of low back pain, is still a great challenge to spinal surgeons and clinicians. T2 mapping, a biochemical magnetic resonance imaging (MRI) technique to calculate relaxation time, has the potential to offer a quantitative assessment of IDD.
The aim of the study was to evaluate the regenerative effects of adipose-derived mesenchymal stem cells (MSCs) encapsulated in PEGDA-microcryogels (PMs) reinforced alginate hydrogel (AH) on the degenerative intervertebral disc (IVD) in a canine model using T2 mapping.