Osteoarthritis

Authors: Dingemanse WB, Van Bree HJ, Duchateau L, Gielen IM.
Journal: Vet Surg

OBJECTIVE:
To evaluate clinical and subchondral bone lesion differences between medial (MTRT-OC) and lateral trochlear ridge tarsocruralosteochondrosis (LTRT-OC).
STUDY DESIGN:
Retrospective case series.
ANIMALS:
Dogs (n = 66) with MTRT-OC or LTRT-OC.
METHODS:

Authors: Safra N, Johnson EG, Lit L, Foreman O, Wolf ZT, Aguilar M, Karmi N, Finno CJ, Bannasch DL.
Journal: JAVMA

Objective-To evaluate clinical manifestations, response to treatment, and outcome for Weimaraners with hypertrophic osteodystrophy (HOD). Design-Retrospective case series. Animals-53 dogs. Procedures-Medical records were reviewed for signalment, vaccination history, clinical signs, laboratory test results, response to treatment, and relapses. Radiographs were reviewed. Results-Clinical signs included pyrexia, lethargy, and ostealgia; signs involving the gastrointestinal, ocular, or cutaneous systems were detected. Of the 53 dogs, 28 (52.8%) had HOD-affected littermates.

Authors: Ellenberger S, Snyder C.
Journal: JAAHA

A 3 mo old female Airedale terrier presented with decreased range of motion of the temporomandibular joint (TMJ), which was first recognized at weaning. Computed tomography (CT) revealed abnormal, bilateral ossification of the soft tissues extending from the region of the tympanic bullae to the medial aspect of the angular process of each mandible. Those ossified structures most closely approximated the location of the lateral pterygoid muscles. The ossified structures were present at presentation and initially manifested as complete ossification on the right side.

Authors: Zhang N, Dietrich MA, Lopez MJ.
Journal: Vet Surg

OBJECTIVE:
To identify the optimum intra-articular multipotent stromal cell (MSC) tissue source in the canine stifle.
STUDY DESIGN:
Experimental.
SAMPLE POPULATION:
Infrapatellar adipose tissue, synovium lining the joint capsule, and synovium surrounding the cranial cruciate ligament (CrCL) from normal stifles of 6 dogs.
METHODS:

Authors: Garner BC, Kuroki K, Stoker AM, Cook CR, Cook JL.
Journal: AJVR

Objective-To identify proteins with differential expression between healthy dogs and dogs with stifle joint osteoarthritis secondary to cranial cruciate ligament (CCL) disease. Sample-Serum and synovial fluid samples obtained from dogs with stifle joint osteoarthritis before (n = 10) and after (8) surgery and control dogs without osteoarthritis (9) and archived synovial membrane and articular cartilage samples obtained from dogs with stifle joint osteoarthritis (5) and dogs without arthritis (5).

Authors: Arzi B, Cissell DD, Verstraete FJ, Kass PH, Duraine GD, Athanasiou KA.
Journal: JAVMA

Objective-To describe CT findings in dogs and cats with temporomandibular joint (TMJ) disorders. Design-Retrospective case series. Animals-41 dogs and 17 cats. Procedures-Medical records and CT images of the skull were reviewed for dogs and cats that were examined at a dentistry and oral surgery specialty practice between 2006 and 2011. Results-Of 142 dogs and 42 cats evaluated, 41 dogs and 17 cats had CT findings consistent with a TMJ disorder.

Authors: Benito J, Gruen ME, Thomson A, Simpson W, Lascelles BD.
Journal: J Fel Med Surg

This study evaluated the types of items owners consider important to their cats' quality of life (QoL). We hypothesized that items contributing to QoL in cats are predominantly items requiring mobility.

Authors: Giorgi M, Meizler A, Mills PC.
Journal: Vet J

Tapentadol (TAP) is a novel opioid pain reliever drug with a dual mechanism of action (mu opioid receptor agonist and noradrenaline reuptake inhibitor). It is used as an analgesic in humans, but could be of interest for veterinary species if it has a suitable pharmacokinetic profile. Six dogs were randomly assigned to two treatment groups, using an open, single-dose, two-treatment, two-period, and randomised cross-over design. Each subject received TAP at 50 and 200mg by intravenous (IV) and oral route, respectively, with a 1-week wash-out period between administrations.

Authors: Nishida H, Shoji Y, Nakamura M, Hatoya S, Sugiura K, Yamate J, Kuwamura M, Kotani T, Nakayama M, Suzuki Y, Ide C, Inaba T.
Journal: AJVR

Objective-To compare methods for harvesting canine bone marrow stromal cells (BMSCs) and determine the biological properties of canine BMSCs at successive passages in vitro. Sample-BMSCs collected from the femurs of 9 Beagles. Procedures-A fibroblast assay was performed to compare 2 methods for harvesting BMSCs: the aspiration and perfusion method. Flow cytometric analysis was performed to evaluate the cell surface markers. Changes in proliferative activity were analyzed by examining radioactivity of hydrogen 3-thymidine.

Authors: Gutbrod A, Guerrero TG.
Journal: Vet Surg

OBJECTIVE:
To evaluate the effect of 15° external rotational humeral osteotomy (ERHO) on canine elbow joint contact mechanics.
STUDY DESIGN:
Ex vivo biomechanical study.
SAMPLE POPULATION:
Unpaired cadaveric canine thoracic limbs (n = 8)
METHODS: