Osteoarthritis

Authors: Smith ZF, Wendelburg KL, Tepic S, Stover SM, Garcia-Nolen T, Stearns PB, Hayashi K.
Journal: VCOT

Elbow dysplasia, primarily affecting the medial compartment, is the most common cause of lameness in the thoracic limb. Elbow arthroplasty is an option for end stage or severely affected patients. The purpose of this study was to compare ex vivo axial load to failure of an implanted novel elbow arthroplasty system to control limbs. The partial arthroplasty is a medial compartmental, unconstrained system, intended to allow conversion to total arthroplasty. We hypothesized that there would not be any significant difference between implanted and controlled limbs when loaded to failure.

Authors: Mölsä SH, Hielm-Björkman AK, Laitinen-Vapaavuori OM.
Journal: JAVMA

Objective-To evaluate, by means of an owner questionnaire, long-term outcome and prevalence of chronic pain after cranial cruciate ligament (CCL) surgery in dogs. Design-Retrospective case series. Animals-253 dogs with surgically treated CCL rupture. Procedures-Data from surgical records of dogs that underwent surgical repair of CCL between 2004 and 2006 were reviewed.

Authors: Budsberg SC, Stoker AM, Johnston SA, Liska W, Reno LR, Cook JL.
Journal: AJVR

Objective-To assess effects of in vitro meloxicam exposure on metabolism in articular chondrocytes from dogs with naturally occurring osteoarthritis Sample-Femoral head cartilage from 16 dogs undergoing total hip replacement Procedures-Articular cartilage samples were obtained. Tissue sulfated glycosaminoglycan (SGAG), collagen, and DNA concentrations were measured. Collagen, SGAG, chondroitin sulfate 846, NO, prostaglandin E2 (PGE2), and matrix metalloproteinase (MMP)-2, MMP-3, MMP-9, and MMP-13 concentrations in culture medium were analyzed.

Authors: Rialland P, Bichot S, Lussier B, Moreau M, Beaudry F, Del Castillo JR, Gauvin D, Troncy E.
Journal: Can J Vet Res

This study aimed to establish the effect of a diet enriched with green-lipped mussel (GLM) on pain and functional outcomes in osteoarthritic dogs. Twenty-three client-owned dogs with osteoarthritis (OA) were fed a balanced control diet for 30 d and then a GLM-enriched balanced diet for the next 60 d. We assessed peak vertical force (PVF), which is considered to be the gold standard method, at Day (D)0 (start), D30 (end of control diet), and D90 (end of GLM-enriched diet). The owners completed a client-specific outcome measure (CSOM), which is a pain questionnaire, once a week.

Authors: Aiken MJ, Stewart JE, Anderson AA.
Journal: JSAP

An eight-year-old male neutered Staffordshire bull terrier was presented for investigation of right forelimb lameness of 14 months' duration. Radiography showed mottled osteolysis of the right radial carpal bone. Histopathology of the bone demonstrated replacement of healthy bone with granulation tissue suggestive of ischaemic necrosis. Lameness resolved following pancarpal arthrodesis. In humans, Preiser's disease is a condition in which idiopathic ischaemic necrosis of the scaphoid bone, the equivalent of the canine radial carpal bone, occurs.

Authors: Aiken MJ, Stewart JE, Anderson AA.
Journal: JSAP

An eight-year-old male neutered Staffordshire bull terrier was presented for investigation of right forelimb lameness of 14 months' duration. Radiography showed mottled osteolysis of the right radial carpal bone. Histopathology of the bone demonstrated replacement of healthy bone with granulation tissue suggestive of ischaemic necrosis. Lameness resolved following pancarpal arthrodesis. In humans, Preiser's disease is a condition in which idiopathic ischaemic necrosis of the scaphoid bone, the equivalent of the canine radial carpal bone, occurs.

Authors: Lomas AL, Lyon SD, Sanderson MW, Grauer GF.
Journal: AJVR

Objective-To determine whether tepoxalin alters kidney function in dogs with chronic kidney disease (CKD). Animals-16 dogs with CKD (International Renal Interest Society stage 2 or 3) and osteoarthritis. Procedures-Kidney function was assessed via serum biochemical analysis, urinalysis, urine protein-to-creatinine concentration ratio, urine γ-glutamyl transpeptidase-to-creatinine concentration ratio, iohexol plasma clearance, and indirect blood pressure measurement twice before treatment.

Authors: Dycus DL, Au AY, Grzanna MW, Wardlaw JL, Frondoza CG.
Journal: AJVR

Objective-To determine whether oxidative stress could be induced in canine chondrocytes in vitro. Sample-Chondrocytes obtained from healthy adult mixed-breed dogs. Procedures-Harvested chondrocytes were maintained at 37°C with 5% CO2 for 24 hours. To assess induction of oxidative stress, 2 stimuli were used: hydrogen peroxide and a combination of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α). To determine the effect of hydrogen peroxide, a set of chondrocyte-seeded plates was incubated with control medium alone or hydrogen peroxide (100, 200, or 300μM) for 24 hours.

Authors: de Oliveira El-Warrak A, Rouma M, Amoroso A, Boysen SR, Chorfi Y.
Journal: Can Vet J

This study compared vitamin A, vitamin E, selenium (Se), and L-lactate in blood and synovial fluid in 2 groups of 6 dogs; a control group (without OA) and an osteoarthritic group with spontaneous cranial cruciate ligament rupture and OA. Concentrations of vitamin E were significantly higher in serum than in synovial fluid in both OA (P = 0.006) and control (P = 0.0008) groups. Vitamin E concentration in synovial fluid was significantly higher in the OA group than in the control group (P = 0.009).

Authors: Guillot M, Moreau M, Heit M, Martel-Pelletier J, Pelletier JP, Troncy E.
Journal: Vet J

This study aimed to characterize osteoarthritis (OA)-related chronic pain and disability in experimental cats with naturally occurring OA. Peak vertical ground reaction force (PVF), accelerometer-based motor activity (MA) and the von Frey anesthesiometer-induced paw withdrawal threshold were used to define OA and to test the efficacy of meloxicam. A diagnosis of OA was based on radiographic and orthopedic examinations.