Osteoarthritis

MMP-2 as an early synovial biomarker for cranial cruciate ligament disease in dogs.

Authors: Boland L1, Danger R, Cabon Q, Rabillard M, Brouard S, Bouvy B, Gauthier O.

Journal: Vet Comp Orthop Traumatol

Objectives: To measure the activity of matrix metalloproteinases (MMP)-2 and -9 in synovial fluid from the stifle joints of dogs with cranial cruciate ligament (CrCL) rupture and to compare that to values from contralateral stifle joints and dogs with clinically normal stifle joints. Additionally, the C-reactive protein (CRP) levels were also measured. Methods: Fourteen large breed dogs with unilateral CrCL rupture and 11 large breed normal dogs were included in this prospective clinical study.

Category: Arthritis - Biologics - Knee - Osteoarthritis - Tendon and Ligament Injuries

Therapeutic options for the treatment of chronic pain in dogs.

Authors: Macfarlane PD1, Tute AS, Alderson B.

Journal: JSAP

Chronic pain is a widely recognised problem in humans and is being increasingly recognised as a significant problem in dogs. Whilst a large number of therapies are described and utilised to treat chronic pain in dogs, there is a severe shortage of evidence to guide practitioners in selection of treatments. Until more evidence becomes available, practitioners should adopt a cautious approach, utilising licensed treatments first when possible. Non-pharmacological therapies should be incorporated into the chronic pain management plan whenever possible.

Category: Arthritis - Oncology - Osteoarthritis - Pain Management

Comparison of meloxicam and a glucosamine-chondroitin supplement in management of feline osteoarthritis. A double-blind randomised, placebo-controlled, prospective trial.

Authors: Sul RM, Chase D, Parkin T, Bennett D.

Journal: VCOT

Objective: To compare the efficacy of meloxicam and a glucosamine-chondroitin (Glu-Ch) supplement in the management of feline osteoarthritis (OA). Methods: Prospective, blinded, randomized clinical trial. Cats over eight years of age with clinical signs of chronic OA were assigned to one of two groups and Glu-Ch or meloxicam was administered orally for 70 days, followed by a placebo until day 98. Cats were assessed by a veterinarian on five occasions and the owner completed an assessment form at the same time. Results: Data were collected from thirty cats.

Category: Arthritis - Osteoarthritis - Pain Management

Complications of lateral plate fixation compared with tension band wiring and pin or lag screw fixation for calcaneoquartal arthrodesis. Treatment of proximal intertarsal subluxation occurring secondary to non-traumatic plantar tarsal ligament disruption

Authors: Barnes DC, Knudsen CS, Gosling M, McKee M, Whitelock RG, Arthurs GI, Ness MG, Radke H, Langley-Hobbs SJ

Journal: VCOT

Objective: To compare complication rates and the outcomes of these complications after lateral plate fixation with figure-of-eight tension-band-wire and pin or lag screw fixation for arthrodesis of the calcaneo-quartal joint, following non-traumatic disruption of the plantar tarsal ligament in dogs. Methods: Data were collected retrospectively from five UK referral centres. Diplomate specialists and their residents performed all procedures. Referring veterinarians were contacted for long-term follow-up. Results: Seventy-four procedures were undertaken in 61 dogs.

Category: Arthritis - Fracture Fixation and Implants - Hock - Osteoarthritis - Tendon and Ligament Injuries - Trauma

A randomized controlled trial of the efficacy of autologous platelet therapy for the treatment of osteoarthritis in dogs.

Authors: Fahie MA, Ortolano GA, Guercio V, Schaffer JA, Johnston G, Au J, Hettlich BA, Phillips T, Allen MJ, Bertone AL.

Journal: JAVMA

Objective-To determine efficacy of a single intra-articular injection of an autologous platelet concentrate for treatment of osteoarthritis in dogs. Design-Randomized, controlled, 2-center clinical trial. Animals-20 client-owned dogs with osteoarthritis involving a single joint. Procedures-Dogs were randomly assigned to a treatment or control group. In all dogs, severity of lameness and pain was scored by owners with the Hudson visual analog scale and the University of Pennsylvania Canine Brief Pain Inventory, respectively, and peak vertical force (PVF) was determined with a force platform.

Category: Arthritis - Biologics - Osteoarthritis - Pain Management

Prospective trial of autologous conditioned plasma versus hyaluronan plus corticosteroid for elbow osteoarthritis in dogs.

Authors: Franklin SP, Cook JL.

Journal: Can Vet J

This prospective, randomized, double-blinded trial compared outcomes in dogs with bilateral elbow osteoarthritis (OA) treated with hyaluronan plus methylprednisolone (HA + S) or autologous conditioned plasma (ACP(®); Arthrex). An investigator blinded to the treatments graded lameness (0-4) before and 6 months after a single injection with either HA + S or ACP. Clients were blinded to treatment and completed a validated survey before and 1, 6, 12, and 24 weeks after injection. Ten dogs (5 per group) completed all parts of the study.

Category: Arthritis - Biologics - Elbow - Osteoarthritis - Pain Management

Prospective trial of autologous conditioned plasma versus hyaluronan plus corticosteroid for elbow osteoarthritis in dogs.

Authors: Franklin SP, Cook JL.

Journal: Can Vet J

Category: Arthritis - Biologics - Elbow - Osteoarthritis - Pain Management

Anti-inflammatory response of dietary vitamin E and its effects on pain and joint structures during early stages of surgically induced osteoarthritis in dogs.

Authors: Rhouma M, de Oliveira El Warrak A, Troncy E, Beaudry F, Chorfi Y.

Journal: Can J Vet Res

There is evidence that vitamin E (VE) has anti-inflammatory and analgesic properties in human osteoarthritis (OA). This double-blinded and randomized pilot study used a broad spectrum of clinical and laboratory parameters to investigate whether such beneficial effects could be detected in a canine experimental OA model. Dogs were divided into 2 groups: control (n = 8), which received a placebo, and test group (n = 7), which received 400 IU/animal per day of VE for 55 d, starting the day after transection of the cranial cruciate ligament.

Category: Arthritis - Biologics - Osteoarthritis - Pain Management

The use of planar bone scintigraphy and HiSPECT for diagnosis of primary and concomitant flexor enthesopathy in the canine elbow.

Authors: de Bakker E, Peremans K, Vermeire S, Vandermeulen E, Dobbeleir A, Dik KJ, Gielen I, Saunders JH, Van Ryssen B

Journal: VCOT

Objective: To investigate the possibilities and limitations of planar bone scintigraphy and high resolution single photon emission computed tomography (HiSPECT) to diagnose flexor enthesopathy and to distinguish primary flexor enthesopathy from the concomitant form. Materials and methods: A prospective study of 46 dogs with primary flexor enthesopathy, concomitant flexor enthesopathy, medial coronoid disease, and normal elbows was performed. All dogs underwent planar bone scintigraphy and HiSPECT imaging.

Category: Arthritis - Elbow - Imaging - Osteoarthritis - Pain Management - Rehabilitation - Tendon and Ligament Injuries

In vitro biomechanical comparison of load to failure testing of a canine unconstrained medial compartment elbow arthroplasty system and normal canine thoracic limbs.

Authors: Smith ZF, Wendelburg KL, Tepic S, Stover SM, Garcia-Nolen T, Stearns PB, Hayashi K.

Journal: VCOT

Elbow dysplasia, primarily affecting the medial compartment, is the most common cause of lameness in the thoracic limb. Elbow arthroplasty is an option for end stage or severely affected patients. The purpose of this study was to compare ex vivo axial load to failure of an implanted novel elbow arthroplasty system to control limbs. The partial arthroplasty is a medial compartmental, unconstrained system, intended to allow conversion to total arthroplasty. We hypothesized that there would not be any significant difference between implanted and controlled limbs when loaded to failure.

Category: Arthritis - Elbow - Fracture Fixation and Implants - Osteoarthritis - Pain Management