Osteoarthritis

Authors: Byron CR, Stewart MC, Stewart AA, Pondenis HC.
Journal: AJVR

OBJECTIVE: To evaluate the effects of glucosamine on equine articular chondrocytes and synoviocytes at concentrations clinically relevant to serum and synovial fluid concentrations. SAMPLE POPULATION: Articular cartilage and synovium with normal gross appearance from metacarpophalangeal and metatarsophalangeal joints of 8 horses (1 to 10 years of age). PROCEDURES: In vitro chondrocyte and synoviocyte cell cultures from 8 horses were treated with glucosamine (0.1 to 20 microg/mL) with or without interleukin-1 (IL-1; 10 ng/mL) for 48 hours.

Authors: Hossain MA, Park J, Choi SH, Kim G.
Journal: VCOT

Dexamethasone (Dexa) has been commonly used in humans and domestic animals, particularly in the treatment of tendon injuries and cartilage degeneration. However, it is often associated with tendon rupture and impaired tendon and cartilage healing. In the present study, we investigated Dexa's in vitro effects on the growth of cell proliferation and the induction of apoptosis in canine Achilles tendon cells and chondrocytes.

Authors: Arnott JL, Bailey R, Shields A, Bennett D.
Journal: VCOT

Several techniques have been described for canine pancarpal arthrodesis (PCA) with dorsal plating becoming the most accepted method for ease of placement despite the proposed biomechanical disadvantages. The aim of this study was to compare the biomechanical effects of the addition of crossed K-wires to a standard 2.7/3.5 mm hybrid PCA plate. A 2.7/3.5 mm hybrid PCA plate, alone and combined with crossed K-wires were tested. Six pairs of cadaver forelimbs were collected from medium-sized dogs with an average weight of 24 kg by elbow disarticulation.

Authors: Case JB, Hulse D, Kerwin SC, Peycke LE.
Journal: VCOT

OBJECTIVE: To describe clinical signs, arthroscopic findings, and outcome in a group of dogs undergoing second look arthroscopy for the treatment of meniscal tears following original surgery to correct a CCL deficient stifle joint. METHODS: The medical records of 26 dogs from the Veterinary Teaching Hospital at Texas A&M University and the Veterinary Orthopedic Center (Round Rock, Texas) that had second look arthroscopy for lameness following an original surgical procedure were reviewed.

Authors: Vezzoni A, Bohorquez Vanelli A, Modenato M, Dziezyc J, Devine Slocum T.
Journal: VCOT

The purpose of this study was to evaluate the ability of proximal tibial epiphysiodesis to reduce the tibial plateau slope in young dogs with cranial cruciale ligament (CCL) deficient stifles. Of the 14 treated dogs, eight had a bilateral injury, for a total of 22 joints. After physical and radiographical examination and measurement of tibial plateau slope, all of the dogs underwent surgery.

Authors: Vezzoni A, Dravelli G, Vezzoni L, De Lorenzi M, Corbari A, Cirla A, Nassuato C, Tranquillo V.
Journal: VCOT

OBJECTIVES: To evaluate the efficacy of juvenile pubic symphysiodesis (JPS) in a clinical setting for the early treatment of canine hip dysplasia (CHD), and to identify its indications and contraindications. METHODS: The final degree of CHD using the FCI (Fédération Cynologique Internationale) CHD classification in 5 Grades (A, B, C, D, E) was assessed at skeletal maturity in two homogeneous groups of dogs assessed at the age of 14 to 22 weeks and selected according to their susceptibility to CHD; one group was treated with JPS and one group was conservatively managed.

Authors: Cook JL, Hudson CC, Kuroki K.
Journal: Vet Surg

OBJECTIVE: To develop and assess clinical outcomes for osteochondral autografting for treatment of stifle osteochondrosis (OC) in dogs. STUDY DESIGN: Retrospective case series. ANIMALS: Dogs with stifle OC (n=10). METHODS: Osteochondral autografting was developed and optimized in canine cadavers and purpose-bred research dogs using the Osteochondral Autograft Transfer System (OATS). Dogs with stifle OC (n=10 dogs, 12 stifles) were then treated using the OATS system.

Authors: Wigger A, Tellhelm B, Kramer M, Rudorf H.
Journal: Vet Radiol Ultrasound.

We investigated the prevalence of an anatomic variant of the proximal femur, termed the broomstick-like femoral head and neck formation, and its influence on the Féderation Cynologique Internationale (FCI) hip dysplasia score in 294 German Shepherd dogs. One-hundred and eighty (61%) of the 294 dogs in our study had this anatomic variant. The calculated area of the femoral heads in dogs with a broomstick-like conformation was 4.5 +/- 0.6 cm2 on the hip-extended view.