Biologics

Authors: Sura R, Hinckley LS, Risatti GR, Smyth JA.
Journal: Vet Rec

Necrotising fasciitis and necrotising myositis are rare but serious life threatening conditions reported mainly in human beings and dogs. Most cases to date have been caused by beta-haemolytic streptococci of Lancefield groups A, B, C or G. Necrotising fasciitis has been reported only twice in cats and necrotising myositis has never been described. This paper describes a fatal case of necrotising fasciitis and myositis with pneumonia and septicaemia in a nine-year-old cat.

Category: Biologics
Authors: Wooten JG, Blikslager AT, Ryan KA, Marks SL, Law JM, Lascelles BD.
Journal: AJVR

Objective-To assess cyclooxygenase (COX) expression and prostanoid concentrations in pyloric and duodenal mucosae of dogs after administration of nonsteroidal anti-inflammatory drugs (NSAIDs). Animals-8 healthy dogs. Procedures-Each dog received carprofen (4.4 mg/kg, q 24 h), deracoxib (2 mg/kg, q 24 h), aspirin (10 mg/kg, q 12 h), and placebo (1 dog treat, q 24 h) orally for 3 days (4-week interval between treatments).

Authors: Leblanc CJ, Horohov DW, Bauer JE, Hosgood G, Mauldin GE.
Journal: AJVR

Objective-To evaluate the effect of diets enriched with eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on in vivo production of interleukin (IL)-1, IL-6, tumor necrosis factor (TNF)-alpha, prostaglandin E(2) (PGE(2)), and platelet-activating factor (PAF) in dogs. Animals-15 young healthy dogs. Procedures-Dogs were randomly allocated to receive an isocaloric ration supplemented with sunflower oil (n = 5), fish oil (5), or fish oil plus vitamin E (5) for 12 weeks.

Authors: Hosoya K, Murahari S, Laio A, London CA, Couto CG, Kisseberth WC.
Journal: AJVR

Objective-To evaluate the biological activity of dihydroartemisinin on canine osteosarcoma cell lines in vitro. Sample Population-4 canine osteosarcoma cell lines. Procedures-Cell viability assays were performed on canine osteosarcoma cell lines OSCA2, OSCA16, OSCA50, and D17 after 24, 48, and 72 hours of treatment with dihydroartemisinin at concentrations of 0.1 to 100muM. Apoptosis was assessed by use of an ELISA for free nuclosomal DNA fragmentation and by western blot analysis for cleavage of caspase 3.

Category: Biologics - Oncology
Authors: Sheahan DE, Gillian TD.
Journal: JSAP

A six-year-old border collie was presented with a solid mass on the dorsal cranium. Histological examination showed the mass to be a multilobular tumour of bone. A magnetic resonance imaging scan confirmed deformation of the dorsal cranium with compression of the cerebral hemispheres. A craniotomy was performed to excise the mass and overlying skin, resulting in a substantial deficit of calvarium and skin. A cranioplasty using a small intestinal submucosal (SIS) graft was performed to reconstruct the calvarial defect.

Authors: Barry SL, Lafuente MP, Martinez SA
Journal: JAVMA

Case Description-A 3-year-old spayed female Labrador Retriever was evaluated for progressive lameness of the left forelimb 21 months after being shot in the elbow with a lead bullet. Clinical Findings-Physical examination findings were consistent with moderate osteoarthritis of the left elbow joint. Orthogonal radiographic views of the elbow revealed multiple metallic fragments in and around the joint space as well as signs of osteoarthritis.

Category: Arthritis - Biologics
Authors: Bernard F, Furneaux R, Adrega Da Silva C, Bardet JF.
Journal: Vet Comp Orthop Traumatol.

rhBMP-2 solution on a collagen sponge was placed along the diaphysis of an atrophicradius, which had a history of recurring fractures. Two months after rhBMP-2 treatment, new mineralized bone was present, which significantly increased the diameter of the radius and allowed the removal of the external skeletal fixator (ESF). Due to carpo-metacarpal joint compromise, a pancarpal arthrodesis was performed seven months later. At follow-up evaluation two years later the dog was only very mildly lame.

Authors: Weese S.
Journal: Vet Comp Orthop Traumatol.

Surgical site infections caused by bacteria that are resistant to multiple classes of antimicrobials are an important and increasing problem in veterinary medicine. Organisms such as methicillin-resistant staphylococci, extended spectrum beta-lactamase Enterobacteriaceae and multi-drug resistant Enterococcus, Acinetobacter and Pseudomonas spp. are among the current concerns; however, the emergence and dissemination of other multi-drug resistant organisms will likely follow.

Category: Biologics
Authors: Takanosu M, Takanosu T, Suzuki H, Suzuki K.
Journal: J Small Anim Pract.

This report describes an autosomal incomplete dominant pattern of inheritance for osteochondrodysplasia in the Scottish Fold cats. A three-generation pedigree was analysed. Cats with folded ears were mated with cats with normal ears. All cats with folded ears, which were presumably heterozygous for the mutated allele, developed osteochondrodysplasia in distal fore- and hindlimbs but not in other bones, including the tail in which bone deformity had been demonstrated in previous studies.

Category: Biologics - Pediatrics
Authors: McLean CL, Ness MG.
Journal: J Small Anim Pract.

Objectives: To evaluate staff nasal colonisation with meticillin-resistant Staphylococcus aureus in a veterinary orthopaedic referral hospital, and its effect on the occurrence of meticillin-resistant Staphylococcus aureus-associated postoperative wound complications in orthopaedic and spinal surgical patients.

Category: Biologics