Biologics

Authors: Trencart P, Elce YA1, Rodriguez Batista E, Michaud G.
Journal: VCOT

Introduction: Ethylene oxide is currently recommended for sterilization of antibiotic impregnated beads; however this method carries health risks to personnel and is becoming less available. Objective: To perform a pilot study of the effect of radiation for sterilization of polymethylmethacrylate (PMMA) and plaster of Paris (POP) beads impregnated with amikacin, enrofloxacin, and ceftiofur. Hypothesis: Radiation would effectively sterilize the beads without affecting the efficacy of the antibiotic.

Authors: Trencart P, Elce YA1, Rodriguez Batista E, Michaud G.
Journal: VCOT

Introduction: Ethylene oxide is currently recommended for sterilization of antibiotic impregnated beads; however this method carries health risks to personnel and is becoming less available. Objective: To perform a pilot study of the effect of radiation for sterilization of polymethylmethacrylate (PMMA) and plaster of Paris (POP) beads impregnated with amikacin, enrofloxacin, and ceftiofur. Hypothesis: Radiation would effectively sterilize the beads without affecting the efficacy of the antibiotic.

Authors: Hayes GM1, Gibson TW, Moens NM, Monteiro B, Johnson RJ.
Journal: Vet Surg

OBJECTIVE:
To investigate local and systemic pharmacokinetics of gentamicin after intra-articular implantation of a gentamicin impregnated collagen sponge (GICS) in the inflamed canine joint.
STUDY DESIGN:
Descriptive repeated measures experimental study.
ANIMALS:
Dogs (n = 9).
METHODS:

Category: Biologics
Authors: Rousseau M1, Anderson DE, Lillich JD, Apley MD, Jensen PJ, Biris AS.
Journal: AJVR

Objective-To determine the response of cortical bone to a multicomponent and nanostructural polymeric matrix as a drug delivery system for enhancing bone healing. Animals-20 healthy adult crossbred goats.

Authors: Warnock JJ1, Spina J2, Bobe G3, Duesterdieck-Zellmer KF2, Ott J2, Baltzer WI2, Bay BK4.
Journal: Vet J

Meniscal injury is a common cause of canine lameness. Tissue engineered bioscaffolds may be a treatment option for dogs suffering frommeniscal damage. The aim of this study was to compare in vitro meniscal-like matrix formation and biomechanical properties of porcine intestinal submucosa sheets (SIS), used in canine meniscal regenerative medicine, to synoviocyte-seeded SIS bioscaffold (SSB), cultured with fetal bovine serum (SSBfbs) or chondrogenic growth factors (SSBgf).

Category: Biologics - Knee
Authors: Etchepareborde S, Barthelemy N, Brunel L, Claeys S, Balligand M.
Journal: VCOT

Objectives: to evaluate in vitro the strength of different compositions of beta-tricalcium phosphate (β-TCP) wedges in comparison with titanium foam and cages. To study the response to cyclic loading of the strongest β-TCP wedge, titanium foam and titanium cage. Methods: Compression test: Twenty-five tibiae were prepared for tibial tuberosity advancement using the modified Maquet technique.

Authors: Warnock JJ1, Spina J2, Bobe G3, Duesterdieck-Zellmer KF2, Ott J2, Baltzer WI2, Bay BK4.
Journal: Vet J

Meniscal injury is a common cause of canine lameness. Tissue engineered bioscaffolds may be a treatment option for dogs suffering frommeniscal damage. The aim of this study was to compare in vitro meniscal-like matrix formation and biomechanical properties of porcine intestinal submucosa sheets (SIS), used in canine meniscal regenerative medicine, to synoviocyte-seeded SIS bioscaffold (SSB), cultured with fetal bovine serum (SSBfbs) or chondrogenic growth factors (SSBgf).

Category: Biologics - Knee
Authors: Stewart M.
Journal: VCOT

No Abstract

Category: Biologics
Authors: Fahie MA, Ortolano GA, Guercio V, Schaffer JA, Johnston G, Au J, Hettlich BA, Phillips T, Allen MJ, Bertone AL.
Journal: JAVMA

Objective-To determine efficacy of a single intra-articular injection of an autologous platelet concentrate for treatment of osteoarthritis in dogs. Design-Randomized, controlled, 2-center clinical trial. Animals-20 client-owned dogs with osteoarthritis involving a single joint. Procedures-Dogs were randomly assigned to a treatment or control group. In all dogs, severity of lameness and pain was scored by owners with the Hudson visual analog scale and the University of Pennsylvania Canine Brief Pain Inventory, respectively, and peak vertical force (PVF) was determined with a force platform.

Authors: Franklin SP, Cook JL.
Journal: Can Vet J

This prospective, randomized, double-blinded trial compared outcomes in dogs with bilateral elbow osteoarthritis (OA) treated with hyaluronan plus methylprednisolone (HA + S) or autologous conditioned plasma (ACP(®); Arthrex). An investigator blinded to the treatments graded lameness (0-4) before and 6 months after a single injection with either HA + S or ACP. Clients were blinded to treatment and completed a validated survey before and 1, 6, 12, and 24 weeks after injection. Ten dogs (5 per group) completed all parts of the study.