Oncology

OBJECTIVE: To critically evaluate whether open fracture fixation is a significant risk factor for latent osteosarcoma development.

STUDY DESIGN: Case-control study.

SAMPLE POPULATION: Dogs undergoing open fracture repair and dogs diagnosed with osteosarcoma.

OBJECTIVE: To describe the surgical technique for ischiectomy in the dog and to report the procedure in a case.

STUDY DESIGN: Case report.

ANIMAL: An 11-year-old spayed female mixed breed dog with chondrosarcoma of the ischium.

METHODS: The dog presented for hindlimb lameness and evaluation after a radiographic finding of a lytic lesion confined to the left ischium. Following staging and confirmation of stage 1 disease, an ischiectomy with preservation of the hindlimb was performed.

Category: Hip - Oncology

OBJECTIVE: To evaluate outcomes of dogs and owner satisfaction and perception of their dogs’ adaptation following amputation of a thoracic or pelvic limb.

DESIGN: Retrospective case series.

ANIMALS: 64 client-owned dogs.

Category: Oncology

OBJECTIVE: To evaluate clinical characteristics, outcome, and prognostic variables in a cohort of dogs surviving > 1 year after an initial diagnosis ofosteosarcoma.

DESIGN: Retrospective case series.

ANIMALS: 90 client-owned dogs.

Category: Oncology
Authors: Culp WT1, Olea-Popelka F, Sefton J, Aldridge CF, Withrow SJ, Lafferty MH, Rebhun RB, Kent MS, Ehrhart N.
Journal: JAVMA

Objective-To evaluate clinical characteristics, outcome, and prognostic variables in a cohort of dogs surviving > 1 year after an initial diagnosis ofosteosarcoma. Design-Retrospective case series. Animals-90 client-owned dogs. Procedures-Medical records for an 11-year period from 1997 through 2008 were reviewed, and patients with appendicular osteosarcoma that lived > 1 year after initial histopathologic diagnosis were studied. Variables including signalment, weight, serum alkaline phosphatase activity, tumor location, surgery, and adjuvant therapies were recorded.

Category: Oncology
Authors: Selmic LE1, Lafferty MH, Kamstock DA, Garner A, Ehrhart NP, Worley DR, Withrow SJ, Lana SE.
Journal: JAVMA

Objective-To describe the biological behavior, clinical outcome, and prognostic factors of osteosarcoma of the maxilla, mandible, or calvarium in dogs. Design-Retrospective case series. Animals-183 client-owned dogs with osteosarcoma of the maxilla, mandible, or calvarium. Procedures-Medical records for dogs treated for osteosarcoma of the maxilla, mandible, or calvarium from 1986 through 2012 were reviewed. Dogs with a histopathologic diagnosis of osteosarcoma and treated for a primary tumor arising from these bones of the head were included.

Category: Oncology
Authors: Fuchs A1, Goldner B1, Nolte I1, Schilling N2.
Journal: Vet J

To gain insight into the adaptive mechanisms to tripedal locomotion and increase understanding of the biomechanical consequences of limb amputation, this study investigated kinetic and temporal gait parameters in dogs before and after the loss of a hindlimb was simulated. Nine clinically sound Beagle dogs trotted on an instrumented treadmill and the ground reaction forces as well as the footfall patterns were compared between quadrupedal and tripedal locomotion.

Authors: Sartor AJ, Ryan SD, Sellmeyer T, Withrow SJ, Selmic LE1.
Journal: VCOT

OBJECTIVES:

To evaluate the incidence and risk factors for occurrence of osteosarcoma (OSA) following tibial plateau levelling osteotomy (TPLO).

METHODS:

Authors: Amsellem PM1, Selmic LE, Wypij JM, Bacon NJ, Culp WT, Ehrhart NP, Powers BE, Stryhn H, Farese JP.
Journal: J Am Vet Med Assoc

Objective-To describe outcomes for small-breed dogs with appendicular osteosarcoma. Design-Multi-institutional retrospective case series. Animals-51 small-breed dogs. Procedures-Records from participating Veterinary Society of Surgical Oncology members were searched for dogs that weighed ≤ 15 kg (33 lb) with a histologic diagnosis of appendicular osteosarcoma. The Kaplan-Meier method was used to determine median survival times (MSTs), and Cox regression was performed to identify variables associated with survival time.

Category: Oncology
Authors: Neary CP1, Bush WW, Tiches DM, Durham AC, Gavin PR.
Journal: J Am Anim Hosp Assoc

A 12 yr old castrated male mixed-breed dog presented with a 2 wk history of progressive tetraparesis. Neurologic deficits included a short-strided choppy gait in the thoracic limbs and a long-strided proprioceptive ataxia in the pelvic limbs. Withdrawal reflexes were decreased bilaterally in the thoracic limbs. Signs were consistent with a myelopathy of the caudal cervical/cranial thoracic spinal cord (i.e., the sixth cervical [C] vertebra to the second thoracic [T] vertebra).

Category: Oncology - Spine